Safety of PiggyBac Transposon CAR T-cells Targeting CD-19 in Refractory Lupus. (NCT06150651) | Clinical Trial Compass
CompletedPhase 1
Safety of PiggyBac Transposon CAR T-cells Targeting CD-19 in Refractory Lupus.
Thailand3 participantsStarted 2023-12-01
Plain-language summary
A Phase 1 clinical trial to evaluate the safety and efficacy of PiggyBac transposon-mediated Chimeric Antigen Receptor(CAR) T-cells targeting CD19 in refractory Systemic Lupus Erythematosus (SLE) patients who have not responded to standard immunosuppressive treatments.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion criteria
✓. Age between 18 and 60 years.
✓. Diagnosis of Systemic Lupus Erythematosus (SLE), as defined by the American College of Rheumatology (ACR) 1997 criteria, The Systemic Lupus International Collaborating Clinics (SLICC) criteria, or the European Alliance of Associations for Rheumatology (EULAR)/ACR classification.
✓. Refractory SLE, defined by one or more of the following:
✓.1 Persistently active SLE requiring ongoing maintenance therapy (if not contraindicated) with:
✓.2 Biopsy-proven proliferative lupus nephritis after two standard induction therapies, including intravenous cyclophosphamide (cumulative dose of at least 1.5 g) and mycophenolate mofetil (administered for a minimum of 3 months), unless contraindicated.
✓.3 Worsening of biopsy-proven lupus nephritis (activity index \> 6 and chronicity index \< 6 within 6 months), indicated by increased proteinuria and/or decreased estimated glomerular filtration rate, despite treatment with high-dose corticosteroids (prednisolone at least 0.7 mg/kg/day or equivalent) and either mycophenolate mofetil or cyclophosphamide for a minimum of 14 days.
✓. Ability to understand and willingness to sign a written informed consent document.
✓. Participants of child-bearing or child-fathering potential must agree to practice birth control from enrollment until four months after receiving CAR T-cell infusion.
Exclusion criteria
✕. Pregnant or breastfeeding women.
✕
What they're measuring
1
Safety of PiggyBac transposon-mediated CAR T-cell infusion targeting CD19 in adult patients with refractory SLE.
Timeframe: Up to 28 days after CD-19 CAR-T cell infusion
. History of active malignancy, excluding non-melanoma skin cancer and carcinoma in situ (e.g., cervix, bladder, breast).
✕. History of vital organ transplantation (e.g., heart, lung, kidney, liver) or hematopoietic stem cell/bone marrow transplantation.
✕. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, pulmonary abnormalities, cirrhosis, or psychiatric illness/social situations that limit compliance with study requirements.
✕. Any other clinically significant disease history or current disease that, in the judgment of the research physician, may pose a risk to the safety of the subjects or interfere with the research procedure, or the evaluation of safety and efficacy.
✕. Serologic status indicating active HIV, hepatitis B, or C infection. Participants positive for hepatitis B core antibody, hepatitis B surface antigen, or hepatitis C antibody must have a negative PCR prior to enrollment.
✕. History of severe adverse drug reaction to Cyclophosphamide or Fludarabine.
✕. Received a live vaccine within 30 days prior to CAR-T cell infusion.