The research area that focuses on the links between nutrition and health, nutrition and the immune system as well as nutrition-related public health interventions, which often falls into the gap between the agricultural and health domains. The rationale of this project is to study the influence of beneficial diets on the immune system of pre-diabetic patients and its potential to counteract infections. A clinical, an in vitro (cell systems) and an in vivo (animal model) approach will be used to study the influence of a seaweed bioactive supplement and a diet rich in components from a Mediterranean diet on a Salmonella typhimurium infection in prediabetic subjects. At the end of this project, we will provide evidence on the potential of these nutritional interventions to counteract infection, which are of high relevance to the society to reduce the burden of type 2 diabetes (T2DM) and obesity. This research is part of an ongoing research project funded by the Research State Agency (Spain), Health Research Board (HRB, Ireland) and the Medical Research Council (MRC-UKRI, UK) via the NUTRIMMUNE' Grant of the Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI-HDHL).
Age range
18 Years – 65 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Changes in blood glucose levels
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention
Changes in insulin sensitivity
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention
Changes in gut microbiome
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention
Changes in pro and anti-inflammatory biomarkers
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention
Changes in metabolic profile
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention
Changes in dietary habits
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention
Changes in blood pressure
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention
Changes in quality of life
Timeframe: Changes from baseline to 6 and 12 weeks of the intervention