WithdrawnNot Applicable

HIIT in Isolated IFG: A Proof-of-Concept Study

Stopped: Due to operational issues

0Started 2026-06-01

Plain-language summary

This pilot randomized controlled trial will involve 34 physically inactive adults aged 35-65 years with overweight or obesity and isolated impaired fasting glucose (i-IFG). The study aims to assess the feasibility of recruiting and retaining participants, implementing study procedures, and evaluating the acceptability of a high-intensity interval training (HIIT) intervention. Additionally, it will investigate the preliminary efficacy of HIIT in reducing fasting plasma glucose levels and addressing the pathophysiology of i-IFG.

Who can participate

Age range

35 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Males and females aged 35-65 years
. Any race or ethnicity
. BMI ≥25 kg/m2 (≥23 kg/m2 if Asian decent)
. Physically inactive (\<150 min of moderate-intensity or \<75 min of vigorous-intensity aerobic physical activity/week)
. Will be residing in the same location until completion of the study
. Isolated impaired fasting glucose on the OGTT: FPG 100-125 mg/dl and 2-hr plasma glucose \<140 mg/dl

Exclusion criteria

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Response rate in %

Timeframe: Baseline

Screening yield in %

Timeframe: Baseline

Enrolment rate in %

Timeframe: Baseline

Time to enrollment (mins)

Timeframe: Baseline

Intervention compliance in %

Timeframe: 8 weeks

Program costs (USD)

Timeframe: From baseline to 8 weeks

Staff time (mins)

Timeframe: From baseline to 8 weeks

Retention rate in %

Timeframe: 8 weeks

Trial details

NCT IDNCT06143345

SponsorEmory University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-30

View on ClinicalTrials.gov More Isolated Impaired Fasting Glucose trials

Plain-language summary

Who can participate

Age range

35 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Males and females aged 35-65 years
. Any race or ethnicity
. BMI ≥25 kg/m2 (≥23 kg/m2 if Asian decent)
. Physically inactive (\<150 min of moderate-intensity or \<75 min of vigorous-intensity aerobic physical activity/week)
. Will be residing in the same location until completion of the study
. Isolated impaired fasting glucose on the OGTT: FPG 100-125 mg/dl and 2-hr plasma glucose \<140 mg/dl

Exclusion criteria

What they're measuring

Response rate in %

Timeframe: Baseline

Screening yield in %

Timeframe: Baseline

Enrolment rate in %

Timeframe: Baseline

Time to enrollment (mins)

Timeframe: Baseline

Intervention compliance in %

Timeframe: 8 weeks

Program costs (USD)

Timeframe: From baseline to 8 weeks

Staff time (mins)

Timeframe: From baseline to 8 weeks

Retention rate in %

Timeframe: 8 weeks