A 28-day Clinical Study on Facial Skin Rejuvenation

Inclusion Criteria: * females aged 30-50 * no history of cosmetic allergies * according to SKIN AGING ATLAS 2(Asian Type), the scores of under-eye wrinkles, pore appearance, forehead wrinkles are all \> 2 * non-sensitive skin * acceptable for split-face use of products for 28 days * no using history of antibiotic in the past three months * written informed consent and portrait right consent were obtained from all participants before study entry Exclusion Criteria: * subjects with known allergies or sensitivities to the ingredients in any of the study products * anyone who is pregnant, nursing an infant, or planning a pregnancy during the study * any symptoms of facial flushing, erythema, papules, desquamation, or edema as evaluated by a physician prior to initial screening or Fotona4D Pro treatment * unhealed skin lesions * participated in any other clinical trial within one month * received facial skin treatments including but not limited to lasers, chemical peels, dermal fillers within one year * taken/injected anti-allergy medication in the past one month * other medical reasons that could affect the test results * participants in other clinical trials at the same time