Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic… (NCT06139692) | Clinical Trial Compass
RecruitingPhase 4
Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke
China810 participantsStarted 2023-11-21
Plain-language summary
This study aims to conduct a multicenter, prospective, randomized clinical trial to scientifically evaluate the safety and efficacy of different perioperative sedation methods during endovascular thrombectomy in acute ischemic stroke patients with large vessel occlusion in the anterior circulation.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age ≥18 years
✓. Presenting with symptoms of acute ischemic stroke
✓. CTA or MRA confirmed occlusion of the anterior circulation (intracranial carotid artery or M1, M2 segment of the middle cerebral artery)
✓. Randomization finished within 24 hours of symptom onset or time last know well
✓. Pre-stroke mRS score ≤2
✓. NIHSS score ≥6 at the time of randomization
✓. ASPECTS value ≥3
✓. Informed consent signed
Exclusion criteria
✕. Pregnant or lactating women
✕. Known allergy to contrast agents or nitinol devices
✕. Known allergy to midazolam or other benzodiazepines
✕. Known allergy to dexmedetomidine or its components
✕. Planned to receive general anesthesia for EVT
✕. Uncontrolled hypertension or hypotension (defined as systolic blood pressure \>185 mmHg or \< 90 mmHg, diastolic blood pressure \>110 mmHg or \< 60 mmHg)