The Effect of Glucose-dependent Insulinotropic Polypeptide on the Alpha Cell Response to Hypoglycaemia in Patients with Type 1 Diabetes

Inclusion Criteria: * Caucasian men * Body mass index between 18-27kg/m2 * Type 1 diabetes (T1D) (diagnosed according to the criteria of the World Health Organization) with HbA1c\<69 mmol/mol (\<8.5%) * T1D duration of 2-30 years * C-peptide negative (stimulated C-peptide ≤ 100 pmol/l) * Treatment with a stable basal-bolus or insulin pump regimen for ≥3 months * Informed consent Exclusion Criteria: * Anaemia (haemoglobin below normal range) * Liver disease (ALAT and/or ASAT \>2 times normal values) or history of hepatobiliary disorder * Late microvascular complications except mild nonproliferative retinopathy * Allergy or intolerance to ingredients included in the standardized meals * Prior myocardial infarction or other cardiac events * Any physical or psychological condition that the investigator feels would interfere with trial participation * Treatment with any glucose-lowering drugs beside insulin