WONDER-02 Trial: Plastic Stent vs. Lumen-apposing Metal Stent for Pancreatic Pseudocysts

Inclusion Criteria: * Patients with pancreatic pseudocyst(s) defined by the revised Atlanta classification * The longest diameter of a targeted pseudocyst ≥ 5 cm * Patients requiring drainage for symptoms associated with a pseudocyst (e.g., infection, gastrointestinal symptoms including abdominal pain, or jaundice) * Patients aged 18 years or older * Written informed consent obtained from patients or their representatives Exclusion Criteria: * A pseudocyst that is inaccessible via the EUS-guided approach * A plastic or lumen-apposing metal stent in situ * Coagulopathy (e.g., platelet count \< 50,000/mm3 or prothrombin time international normalised ratio \[PT-INR\] \>1.5) * Users of antithrombotic agents that cannot be discontinued according to the Japan Gastroenterological Endoscopy Society \[JGES\] guidelines * Patients who do not tolerate endoscopic procedures * Pregnant women