A randomised, open-label study evaluating the pharmacokinetics, safety, and tolerability of a new once daily dose of 900mg of TETA 4HCL by comparing it against the current marketed Cuprior® formulation (450mg trientine base, twice daily) in healthy male and female participants.
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Plasma Concentrations (AUC) of TETA 4HCL Following Administration of Two TETA 4HCL Tablet Formulations.
Timeframe: Up to 48 hours post first dose initiation.
Plasma Concentrations (AUC) of N1-acetyltriethylenetetramine (MAT) Following Administration of Two TETA 4HCL Tablet Formulations.
Timeframe: Up to 48 hours post first dose initiation.
Plasma Concentrations (AUC) of N1, N10-diacetyltriethylenetetramine (DAT) Following Administration of Two TETA 4HCL Tablet Formulations.
Timeframe: Up to 48 hours post first dose initiation.
Pharmacokinetic Parameters (AUC) of TETA in Plasma
Timeframe: Up to 48 hours post first dose initiation.
Plasma Concentrations (Cmax) of TETA 4HCL Following Administration of Two TETA 4HCL Tablet Formulations.
Timeframe: Up to 48 hours post first dose initiation.
Pharmacokinetic Parameters (Time) of TETA in Plasma
Timeframe: Up to 48 hours post first dose initiation.
Pharmacokinetic Parameters (Concentration) of TETA in Plasma
Timeframe: Up to 48 hours post first dose initiation.
Pharmacokinetic Parameters (AUC) of MAT in Plasma
Timeframe: Up to 48 hours post first dose initiation
Plasma Concentrations (Cmax) of N1-acetyltriethylenetetramine (MAT) Following Administration of Two TETA 4HCL Tablet Formulations.
Timeframe: Up to 48 hours post first dose initiation.
Pharmacokinetic Parameters (Time) of MAT in Plasma
Timeframe: Up to 48 hours post first dose initiation
Pharmacokinetic Parameters (Concentration) of MAT in Plasma
Timeframe: Up to 48 hours post first dose initiation
Pharmacokinetic Parameters (AUC) of DAT in Plasma
Timeframe: Up to 48 hours post first dose initiation.
Plasma Concentrations (Cmax) of N1, N10-diacetyltriethylenetetramine (DAT) Following Administration of Two TETA 4HCL Tablet Formulations.
Timeframe: Up to 48 hours post first dose initiation.
Pharmacokinetic Parameters (Time) of DAT in Plasma
Timeframe: Up to 48 hours post first dose initiation.
Pharmacokinetic Parameters (Concentration) of DAT in Plasma
Timeframe: Up to 48 hours post first dose initiation.