AMX0035 and Progressive Supranuclear Palsy

Inclusion Criteria: * Male or female 40 to 80 years of age, inclusive * Diagnosis of possible or probable PSP Richardson Syndrome * Presence of PSP symptoms for \<5 years * Score of \<40 on the total (28-item) Progressive Supranuclear Palsy Rating Scale (PSPRS) * Able to walk independently or with minimal assistance * Minimum score of 24 on the Mini Mental State Examination (MMSE) * Must reside outside a skilled nursing facility or dementia care facility at the time of screening. Residence in an assisted living facility is allowed * Must have a study partner willing to attend study visits and provide information on participant's status * Capable of providing informed consent * Capable and willing to comply with trial procedures including visits to the trial clinic, visit requirements and treatment schedule, including MRI scans * Female participants of childbearing potential must agree to use effective birth control for the duration of the study and for 6 months after last dose of study drug. * Males must agree to use effective birth control method for the duration of the study and for 6 months after the last dose of study drug. Men must not plan to donate sperm. Exclusion Criteria: * Require use of a feeding tube * Evidence of any neurological disorder that could explain signs of PSP * Evidence of any clinically significant neurological disorder other than PSP, including significant cerebrovascular abnormalities, vascular dementia, motor neuron disease or ALS, Huntington's…