Active — Not RecruitingNot Applicable

Transcutaneous Spinal Cord Stimulation in Healthy Adults

United States50 participantsStarted 2025-10-20

Plain-language summary

The goal of this study is to understand how transcutaneous spinal cord stimulation (tSCS) waveform, modulation frequency, and stimulation location impact lower extremity muscle activation and participant comfort in adults without neurologic conditions.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion Criteria: * Age 18-75 years old * Able and willing to give written consent and comply with study procedures Exclusion Criteria: * History of stroke or neurologic pathologies (such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, etc.) * Pregnant or nursing * Skin allergies or irritation; open wounds * Utilizing a powered, implanted cardiac device for monitoring or supporting heart function (i.e. pacemaker, defibrillator, or LVAD) * History of seizures or epilepsy * Active cancer or cancer in remission less than 5 years * Metal implants in the back or spine * Painful musculoskeletal dysfunction due to injury or infection * Unstable cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension, uncontrolled diabetes, or chronic emphysema)

What they're measuring

Resting motor threshold

Timeframe: All study visits (1-10), over the course of up to 5 weeks

Continuous stimulation tolerance

Timeframe: All study visits (1-10), over the course of up to 5 weeks

Trial details

NCT IDNCT06116838

SponsorShirley Ryan AbilityLab

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

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