There is a credible basis for lateral prefrontal cortex and insula deep repetitive transcranial magnetic stimulation (dTMS) stimulation as a treatment for cannabis use disorder (CUD), but no studies to date have examined this. Evidence of benefit could expand the treatment options available for CUD but require randomized controlled trials (RCTs) to evaluate its efficacy. Toward an RCT of this intervention, the proposed study is a phase 1 open-label pilot trial of dTMS for adults with CUD. This study will establish the viability of an H4 protocol constituting an active arm of a future double-blind RCT.
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Feasibility of H4 deep dTMS coils in adults with cannabis use disorder.
Timeframe: End of intervention period (~4 weeks)
Tolerability of H4 deep dTMS coils in adults with cannabis use disorder.
Timeframe: End of intervention period (~4 weeks)
Safety of H4 deep dTMS coils in adults with cannabis use disorder.
Timeframe: End of intervention period (~4 weeks)