Study of DF6215 in Patients With Advanced Solid Tumors

Key Inclusion Criteria * Male or female patients ≥ 18 years old. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * An estimated life expectancy of ≥ 3 months. * Adequate hematological function. * Normal pulmonary function. * Adequate hepatic function. * Adequate renal function. * Effective Contraception. * Additional Inclusion Criteria apply to each cohort. Key Exclusion Criteria * Patients receiving chemotherapy, radiotherapy (other than palliative bone-directed radiotherapy), major surgery, or receiving another systemic anticancer therapeutic agent within 28 days before the start of study drug(s) or within 5 half-lives of the previous therapeutic agent (if known), whichever is shorter. * Patients receiving any of the following concurrent anticancer treatments or investigational drugs within 28 days before the start of the study drug(s), or within 5 half-lives of the previous therapeutic agent (if known), whichever is shorter: * Cytoreductive therapy * Radiotherapy (except for palliative bone-directed radiotherapy) * Note: ≤ 2 weeks of palliative radiotherapy for non-CNS disease is permitted. The last radiotherapy treatment must have been performed at least 7 days before the first dose of study drug. * Immune therapy * Cytokine therapy (except for erythropoietin) * Major surgery (excluding prior diagnostic biopsy) * Concurrent systemic therapy with steroids or other immunosuppressive agents. * Note that short-term administration …