Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Inclusion Criteria: * Histopathologically proven diagnosis of glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma * History and physical examination within 28 days prior to enrollment * Karnofsky performance status 70 or greater * Age 18 years or greater * Negative pregnancy test for females of childbearing potential before 1st research MRI, performed in accordance to institutional guidelines. * Plan to receive standard of care 59.4-60 Gy in 30-33 fractions of radiotherapy. Glioblastoma patients over 65 year-old can receive standard of care hypofractionated radiotherapy including 40 Gy in 15 fractions. Exclusion Criteria: * Prior therapy for tumor except for biopsy or resection, including prior radiotherapy to the brain. * Clinical or radiological evidence of metastatic disease outside the brain * Prior malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 2 years