Safety and Efficacy of Oral NXC-736 in Adult Participants With Moderate and Severe Alopecia Areata (NCT06104839) | Clinical Trial Compass
RecruitingPhase 2
Safety and Efficacy of Oral NXC-736 in Adult Participants With Moderate and Severe Alopecia Areata
South Korea73 participantsStarted 2024-09-01
Plain-language summary
The purpose of this study is to evaluate the safety and efficacy of NXC-736 monotherapy in participants with severe alopecia areata (AA).
Who can participate
Age range19 Years – 65 Years
SexALL
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Inclusion Criteria:
* Men or women between ≥19 and ≤65 years of age at the time of informed consent
* Moderate and severe alopecia areata as assessed by a SALT score of 25% ≤ SALT \< 95% at Screening and Day 1/Baseline
* Current episode of hair loss for ≥6 months but \<8 years
* Stable disease condition (no significant growth of hair) in the last 6 months as assessed by the Investigator
* Willing to keep the same hair style and color (eg, hair products, process, and timing for hair appointments) for the duration of the study
Exclusion Criteria:
* Participants with the following medical history confirmed during screening:
* ohter Types of alopecia other than alopecia areata (such as cicatricial/scarring alopecia \[including central centrifugal cicatricial alopecia\], traction alopecia, androgenic alopecia, telogen effluvium, etc.)
* Active scalp inflammation, scalp infection, scalp psoriasis, or any other scalp condition that may interfere with the SALT assessment
* Previous use of Janus kinase (JAK) inhibitor (oral or topical), including participation in clinical studies of JAK inhibitors