E-B-FAHF-2, Multi OIT and Xolair for Food Allergy

Inclusion Criteria: * 6 through 40 years * At least one of the following for each of the 3 study allergens: serum immunoglobulin E (IgE) \>4000 U/L or skin -prick test \>6mm * dose limiting symptoms at a cumulative dose of \<=444 mg protein for 3 allergens as screening double-blind, placebo-controlled food challenge * use of an effective method of contraception by females of child-bearing potential * ability to ingest oat or corn with no allergic reaction Exclusion Criteria: * If baked milk or egg are tolerated (assessed by clinical report), then milk or egg may not be included as a study allergen * Any disorder in which epinephrine is contraindicated such as coronary artery disease, uncontrolled hypertension, and serious ventricular arrhythmias * History of other chronic disease requiring therapy (other than asthma, atopic dermatitis, or rhinitis) * History of eosinophilic gastrointestinal disease * Current participation in any other interventional study * Investigational drug use within 90 days * Subject is on build-up phase of any allergen immunotherapy (prior to maintenance dosing) * Current uncontrolled moderate to severe asthma as defined by: * Forced Expiratory Volume-1 (FEV1) value \<80% predicted or any clinical features of moderate or severe persistent asthma baseline severity (as defined by the 2007 NHLBI Guidelines) and greater than high daily doses of inhaled corticosteroids (as defined for children and adults using dosing tables from the 2007 NHLBI Guidelines…