Immunology of Ebola Vaccine

Inclusion Criteria: * Signed informed consent for study. * For women of childbearing potential: willing to engage in effective methods of contraception starting at least 28 days prior to vaccination and during the study. * Willing to minimize blood and body fluid exposure to others (encourage abstinence, and hand hygiene; discourage contact with blood, vomit, feces without personal protective equipment (PPE) for at least 14 days following vaccine administration. * Willing to forgo blood donation 30 days prior to and for the duration of study participation. Exclusion Criteria: * At risk of travel-related or occupational exposure to Ebola virus such as through laboratory, clinical contact, field work, or in the judgment of the investigator. * Received any Ebola vaccines or have history of Ebola Virus Disease (EVD). * Current or previous diagnosis of immunocompromising condition such as human immunodeficiency virus or other immunosuppressive condition by receiving systemic immunosuppressants or immune-modifying drugs for \>14 days in total within 6 months prior to screening (for corticosteroids: ≥ 10mg/day of prednisone or equivalent) or anticipates the need for immunosuppressive treatment at any time during participation in the study. * Pregnant and/or breastfeeding (must have urine pregnancy test on the day of vaccination and during screening visit) * Known allergy to any component of the rVSV∆G-ZEBOV-GP vaccine products (VSV, albumin, tris, rice protein). * History of seve…