Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer

Inclusion Criteria: * Age ≥ 18 years * Scheduled for total minimally invasive (laparoscopic or robotic and thoracoscopic) transthoracic Ivor Lewis esophagectomy (ttMILE) due to esophageal cancer and subsequent eso-SPONGE application to prevent anastomotic leakage * Patients able to read and understand the Patient Information Sheet and sign, if accepted, the Informed Consent Form * Patients able, at the discretion of the investigator, to comply with the requirements of the study and without impediments to follow the instructions and assessments throughout the study. Exclusion Criteria: * Patients undergoing transhiatal esophagectomy without reconstruction, open Ivor Lewis esophagectomy or other esophageal resections different to ttMILE. * Multi-organ resection during the esophagectomy. * Emergent-urgent esophagectomy. * Coloplasty or small bowel plasty. * Necrotic tissue/gangrene. * Blood clotting disorder. * Bleeding esophageal varices. * Sponge placement required directly on major vessels. * Patients with known sensitivities or allergies to its components * Participation in any other clinical trial and use of any drug or experimental device, currently or in the 4 weeks prior to inclusion in the study. * Women who are pregnant, suspected of being pregnant or breastfeeding.