This study consists of two parts: Part A Surveillance and Part B Transmission. The main purpose of Part A is to evaluate the prevalence of pre-dose and treatment-emergent amino acid substitutions in pediatric participants' \<12 years with influenza treated with baloxavir marboxil. Part B will include a subset of Part A participants who have household contacts (HHCs) recruited to the study. Part B will evaluate the incidence of onward influenza transmission from pediatric index participants (IPs) under 5 years of age and those aged 5 to under 12 years, treated with baloxavir marboxil, to their HHCs. Participants will no longer be enrolled to Part B Transmission as per protocol version 3.
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Part A: Percentage of Participants With Resistance-associated Pre-treatment Substitutions
Timeframe: Day 1 (At Baseline)
Part A: Percentage of Participants With Resistance-associated Treatment-emergent Substitutions
Timeframe: Days 4, 6 and 10
Reference Study ID Number: CV44536 https://forpatients.roche.com/