The Effect of Jiajian Guishen Granules on the Modulation of Ovarian Function in Patients With Poo… (NCT06089395) | Clinical Trial Compass
UnknownEarly Phase 1
The Effect of Jiajian Guishen Granules on the Modulation of Ovarian Function in Patients With Poor Ovarian Response(POR)
China76 participantsStarted 2024-06-01
Plain-language summary
Relying on the Department of Gynecology of Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine and chaoyang hospital of Capital medical university, this randomized controlled clinical study was carried out to investigate the application of kidney tonifying herbs to patients with poor ovarian response（POR）.
A total of 76 patients with POR were collected and stratified district groups were randomly divided into a test group and a control group, with 38 patients included in each group. The experimental group was intervented with JJGS granules + coenzyme Q10 simulant, and the control group was intervened with coenzyme Q10 + JJGS granules simulant. AMH, serum basal sex hormone, AFC, TCM syndrome score, modified Kupperman scale and pregnancy status were observed before and after treatment to investigate the effects of Jiajian Guishen granules on the ovarian function of POR patients.
Who can participate
Age range20 Years – 45 Years
SexFEMALE
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Inclusion criteria
✓. Woman who meet the diagnostic criteria for poor ovarian response;
✓. Woman who meet the TCM diagnostic criteria for kidney deficiency;
✓. Womanwho voluntarily signed the informed consent form.
Exclusion criteria
✕. Woman who have combination of serious diseases such as cardiovascular, cerebrovascular, hepatic, renal and hematopoietic systems, and malignant tumors;
✕. Woman who have other endocrine diseases, such as polycystic ovary syndrome and hyperprolactinemia;
✕. Woman who are unable to cooperate with the treatment and follow-up, such as combined neurological and psychiatric disorders, or those who are unwilling to cooperate.
What they're measuring
1
Anti-Miller's Tube Hormone（AMH）
Timeframe: before treatment and the first menstrual period 2-4 days after treatment