Nebulization Versus Spray-as-You-Go Airway Topical Anesthesia Using Dexmedetomidine and Lidocaineā¦ (NCT06088875) | Clinical Trial Compass
UnknownNot Applicable
Nebulization Versus Spray-as-You-Go Airway Topical Anesthesia Using Dexmedetomidine and Lidocaine Mixture During Awake Flexible Fiberoptic Intubation in Temporomandibular Ankylosis
Egypt50 participantsStarted 2023-10-18
Plain-language summary
The aim of this study is to compare the efficacy of airway topical anesthesia with nebulization to the spray-as-you-go technique using dexmedetomidine and lidocaine mixture to achieve upper airway anesthesia in TMJ ankylosis patients.
Who can participate
Age range21 Years ā 65 Years
SexALL
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Inclusion Criteria:
* Age from 21to 65 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status I or II and scheduled for elective surgery requiring general anesthesia , and known to have Temporomandibular joint ankylosis and expected to be difficult intubation patient due to restriction of jaw mobility and limited mouth opening less than 2 fingers.
Exclusion Criteria:
* History of allergy to dexmedetomidine or lidocaine.
* History of drug abuse.
* Concomitant use of medications which may exaggerate the heart rate (HR) response of -dexmedetomidine (e.g. digoxin or Ī²-adrenergic antagonists), HR \<50 beats/min, systolic blood pressure (SBP) \<90 mmHg.
* Pregnancy.
* Morbid obesity( BMI more than 35).
* Patients on anticoagulants, nasal trauma, deformity or polyp, CSF rhinorrhea, fracture base skull.
* Cardiac and/or respiratory disease, reactive airway disease, hepatic or renal disorders.