Evaluation of the Effect of Different Doses of Ozone Therapy on Pain and Function of Patients With Knee Osteoarthritis

Inclusion Criteria: * Having primary knee osteoarthritis grade 2 and 3 according to the doctor's diagnosis and based on the Kellgren and Lawrence criteria (the presence of knee pain, morning dryness for less than 30 minutes, crypts during movement and radiological signs of osteoarthritis including joint space reduction, subchondral bone sclerosis and osteophyte formation in knee) * Age 50-75 years * Suffering from continuous knee pain for at least six months and with a severity of at least 4 based on the VAS criteria in physical activities such as going up and down the stairs, sitting for a long time and squatting * Ability to walk independently for at least 30 meters * Body mass index equal to or less than 35 * Complete consent of the patient to participate in the research * Balanced mental state Exclusion Criteria: * History of intra-articular injections in the knee during the last six months * Suffering from neuromuscular diseases * Presence of acute traumatic injury in other ligaments and structures of the knee joint as confirmed by a specialist doctor * History of previous surgery or injury in the knee and other joints of the lower limbs during the last year * Presence of bone implants * The presence of new fractures in the lower limbs during the last year * Getting malignant tumors * Participation in sports therapy and physiotherapy programs during the last three months