CompletedNot Applicable

The Kallikrein-Kinin System in Cardiac Surgery

China287 participantsStarted 2023-09-20

Plain-language summary

We aimed to established an interlink among the kallikrein-kinin system (KKS), endothelial dysfunction and POD in response to cardiosurgery , using clinic investigation.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Patients were eligible for enrollment if they met all of the following criteria:
✓. Adult patients aged 18 years or older.
✓. Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB), specifically including open-heart valve repair or replacement.
✓. Provided written informed consent from the patient or a legally authorized representative.

Exclusion criteria

✕. Neurological and Psychiatric Factors:
✕. Surgical and Systemic Factors:
✕. Pharmacological Factors:

What they're measuring

KLK1 level

Timeframe: 24 hours

POD-postoperative delirium

Timeframe: 7 days

Trial details

NCT IDNCT06080295

SponsorQin Zhang

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-30

View on ClinicalTrials.gov More Cardiosurgery trials