SuspendedNot Applicable

Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

Stopped: Funding has ended; seeking additional funding to continue

United States110 participantsStarted 2025-03-17

Plain-language summary

The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25. The main question it aims to answer is: will cannabis users who switch to less potent THC products demonstrate improved cognitive function compared to baseline? Other questions this study aims to answer include: * Can researchers accurately assess THC consumption among frequent cannabis users? * Can researchers effectively incentivize cannabis users to use less potent THC products? * Do genetic variations in THC metabolism impact urinary THC excretion? * Do genetic variations in THC metabolism impact cognitive performance in cannabis users? * Are quantitative urinary THC values predictive of cognitive impairment? * How can researchers use research findings to inform harm reduction practices for people who use cannabis? Participants will submit blood and urine samples and be incentivized to use less potent THC products.

Who can participate

Age range

21 Years – 25 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Between the ages of 21-25 * Resides in San Francisco * Self-report cannabis concentrate use as their primary method of cannabis use * Self-report using cannabis daily or almost daily (i.e., at least 6 out of 7 days during each of the last 4 weeks) * Self-report only purchasing cannabis from regulated retail stores in California. Exclusion Criteria: * Pregnant * Regularly uses other drugs (other than nicotine)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Rapid Visual Information Processing Score

Timeframe: Baseline and 5 weeks

Change in Paired Associates Learning score

Timeframe: Baseline and 5 weeks

Change in Delayed Matching-to-Sample Score

Timeframe: Baseline and 5 weeks

Change in Verbal Recognition Memory score

Timeframe: Baseline and 5 weeks

Change in Spatial Working Memory score

Timeframe: Baseline and 5 weeks

Change in One-Touch Stockings of Cambridge score

Timeframe: Baseline and 5 weeks

Change in Stop Signal Task score

Timeframe: Baseline and 5 weeks

Trial details

NCT IDNCT06077292

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-14

View on ClinicalTrials.gov More Cannabis Use trials

Plain-language summary

Who can participate

Age range

21 Years – 25 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Rapid Visual Information Processing Score

Timeframe: Baseline and 5 weeks

Change in Paired Associates Learning score

Timeframe: Baseline and 5 weeks

Change in Delayed Matching-to-Sample Score

Timeframe: Baseline and 5 weeks

Change in Verbal Recognition Memory score

Timeframe: Baseline and 5 weeks

Change in Spatial Working Memory score

Timeframe: Baseline and 5 weeks

Change in One-Touch Stockings of Cambridge score

Timeframe: Baseline and 5 weeks

Change in Stop Signal Task score

Timeframe: Baseline and 5 weeks