UnknownNot Applicable

The Use of Injectable-Platelet Rich Fibrin (i-PRF) in the Lower Third Molar Extraction

Italy40 participantsStarted 2023-02-27

Plain-language summary

Lower third molar extraction is one of the most frequently performed surgical procedures in dentistry. Common sequelae, including pain, swelling and trismus, can severely affect patients' quality of life during the immediate postoperative period. The aim of this randomized-controlled trial is to clinically evaluate the reduction of lower third molar extraction-related complications, such as swelling and pain, and wound healing, following submucosal infiltration of injectable platelet rich fibrin.

Who can participate

Age range18 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Need for extraction of totally or partially impacted lower third molar * Equivalent degree of difficulty of lower third molar extraction * Patients able to understand and sign informed consent Exclusion Criteria: * General contra-indications for surgery (systemic disease, compromised immune system etc); * Tobacco smoking * Alcohol and drug abuse * Pregnancy and breastfeeding * Patients taking any medications which might interfere with healing * Dysplastic processes in the affected tooth elements * Non-cooperative patients EXCLUSION CRITERIA DURING FOLLOW-UP - Patients who do not adhere throughout the duration of follow-up to the specialist visits POSTOPERATIVE EXCLUSION CRITERIA \- Taking more than two doses of prescribed anti-inflammatory/analgesic medication

What they're measuring

Postoperative swelling

Timeframe: Measurements will be taken before surgery, on day 3 and day 7.

Trial details

NCT IDNCT06073535

SponsorUniversity of Naples

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-04

View on ClinicalTrials.gov More Molar, Third trials