A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)

Inclusion Criteria: * Able to understand and communicate in English language * Female of age 18-43 years * Diagnosis of premature ovarian insufficiency based on ESHRE Guidelines (i) oligo/amenorrhea for at least 4 months, and (ii) an elevated FSH level \>25 IU/L on two occasions \>4 weeks apart, or diagnosis of low ovarian reserve defined as: Basal FSH value \>10 IU/L or failure of prior attempts of assisted reproductive techniques due to limited ovarian response (poor responders) * Normal karyotype 46, XX, and no known history FMR1 premutation (fragile X syndrome) * Baseline AMH levels ≤ 1.0 ng/mL * Presence of at least one ovary * Normal uterine anatomy (by any clinically and/or imaging acceptable methods) * Normal thyroid function as evident by normal serum Thyroid Stimulating Hormone (TSH) levels * For subjects who had contraception before, the duration of amenorrhea should be more than 3 months after discontinuation of the oral contraception pill (OCP) or more than 6 months after discontinuation of Depo Provera (or similar) therapies * Agree to report any pregnancy to the research staff immediately * Willing and able to comply with study requirements and follow up instructions * Patient with known history of endometriosis or polycystic ovarian syndrome * If subject is planning to pursue pregnancy: presence of at least unilateral tubal patency (with any clinically acceptable methods) Exclusion Criteria: * Currently pregnant or breast-feeding * Has a history of, or evid…