This study will investigate the potential drug interactions between vemircopan and metformin, rosuvastatin, levonorgestrel/ ethinyl estradiol (LNG/EE)-containing oral contraceptive(s) (OCs), and carbamazepine in healthy participants.
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Part 1: Maximum observed plasma (peak) concentration (Cmax) of Metformin
Timeframe: Up to 48 hours post-dose
Part 1: AUC from time zero to the last quantifiable concentration (AUCt) of Metformin
Timeframe: Up to 48 hours post-dose
Part 1: AUC from time zero extrapolated to infinity (AUC∞) of Metformin
Timeframe: Up to 48 hours post-dose
Part 1: Cmax of Rosuvastatin
Timeframe: Up to 96 hours post-dose
Part 1: AUCt of Rosuvastatin
Timeframe: Up to 96 hours post-dose
Part 1: AUC∞ of Rosuvastatin
Timeframe: Up to 96 hours post-dose
Part 2: Cmax of LNG
Timeframe: Up to 120 hours post-dose
Part 2: AUCt of LNG
Timeframe: Up to 120 hours post-dose
Part 2: AUC∞ of LNG
Timeframe: Up to 120 hours post-dose
Part 2: Cmax of EE
Timeframe: Up to 120 hours post-dose
Part 2: AUCt of EE
Timeframe: Up to 120 hours post-dose
Part 2: AUC∞ of EE
Timeframe: Up to 120 hours post-dose
Part 3: Cmax of Vemircopan
Timeframe: Up to 72 hours post-dose
Part 3: AUCt of Vemircopan
Timeframe: Up to 72 hours post-dose
Part 3: AUC∞ of Vemircopan
Timeframe: Up to 72 hours post-dose