RecruitingPhase 1

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

United States63 participantsStarted 2025-08-04

Plain-language summary

This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.

Who can participate

Age range21 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) diagnosis of Alcohol Use Disorder * Medically healthy * Ability to provide consent Exclusion Criteria: * Unstable medical conditions

What they're measuring

Safety and tolerability of DMT in women and men with AUD

Timeframe: Day 0 through Day 56

The effects of DMT, plus psychotherapy, on alcohol consumption

Timeframe: Day 0 through Day 56

Trial details

NCT IDNCT06070649

SponsorYale University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08-01

Contact for this trial

Angelina Contreras

(203) 974-7525 angelina.contreras@yale.edu

View on ClinicalTrials.gov More Alcohol Use Disorder (AUD) trials