This is an open i.e. not blinded, cluster-randomised, controlled intervention study. The study will use a factorial design to estimate the protective effectiveness of mass drug administrations, mass vaccinations, combined mass vaccinations and drug administrations versus the current standard of care.
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Falciparum malaria incidence by study groups
Timeframe: Data will be collected for two years following baseline intervention (Month 0 to Month 24)
Falciparum malaria prevalence by study groups
Timeframe: PCR for malaria detection from DBS will be collected at 6th month intervals until two years following baseline intervention (Month 0, Month 6, Month 12, Month 18 and Month 24)
Overall percentage of falciparum malaria positivity by study groups
Timeframe: DBS: Month 0, Month 6, Month 12, Month 18 and Month 24 and Clinical malaria data for two year following intervention