Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined With Endovascular Treatment i… (NCT06064747) | Clinical Trial Compass
CompletedNot Applicable
Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined With Endovascular Treatment in ACute Ischemic StrokE
China60 participantsStarted 2024-05-25
Plain-language summary
This is a multicenter, randomized, double-blind, sham-controlled, investigator-initiated clinical study, to evaluate the clinical efficacy and safety of LF-rTMS in rescuing the ischemic penumbra, reducing disability rate and improving functional outcome in patients with acute ischemic stroke receiving early endovascular recanalization (bridging or direct endovascular therapy)
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. 18 - 80 years, male or female;
✓. Clinically diagnosed as acute anterior ischemic stroke, artery occlusion occurred at the terminal of the intracranial carotid artery, T-shaped bifurcation or M1 segment of the middle cerebral artery;
✓. Within 24 hours of stroke onset;
✓. Eligible for other imaging indications for bridging therapy or direct mechanical thrombectomy:
✓. Planned to receive bridging therapy (endovascular therapy after intravenous alteplase) or direct endovascular therapy;
✓. Pre-morbid modified Rankin Scale ≤1;
✓. 6 ≤ NIHSS ≤ 25 before endovascular therapy;
✓. Signed informed consent from subjects or legally authorized representatives
Exclusion criteria
✕. TMS contraindications include metallic foreign bodies in the head, pacemaker, implantable drug pumps, cochlear implants, etc.
✕. Epilepsy or history of epilepsy, intracranial hypertension, tumor and other serious neurological disorders;
✕. Midline displacement and brain parenchymal mass effect seen in head CT and other images;
✕. Head CT or MRI showed bilateral acute cerebral infarction;