Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intracranial Artery Stenosis

Inclusion Criteria: * Age \> 18 years old * Acute ischemic stroke or TIA with onset \< 7 days * Have a history or newly diagnosed as NVAF * Concomitant stenosis (\>50%) of carotid artery/intracranial artery, of which the ischemic lesion located within the territory Exclusion Criteria: * Chronic renal dysfunction (GFR \< 30ml/min) or severe hepatic injury * Have a history or newly diagnosed as valvular heart disease * Mural thrombus in heart * Contraindications of anticoagulation or antiplatelet therapy, e.g. severe intracranial hemorrhage * Myocardial infarction within 6 months before enrollment or received percutaneous coronary intervention in the past * Have or plan to receive CEA or CAS in the following 3 months * Life expectancy less than 1 year * Plan to receive invasive surgery in the following 3 months and have high risk of uncontrollable bleeding * Pregnant or lactating women * Individuals identified by researchers as unsuitable for participation in the study due to other reasons.