The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
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Adipose lymphocyte populations
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
IL6 secreted from adipose tissue measured using the Olink Target Inflammation Panel (includes 96 inflammation-associated proteins)
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue macrophage populations
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of interleukin (IL)-6 measured by polymerase chain reaction (PCR).
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of interleukin (IL)-8 measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of cluster of differentiation 68 (CD68) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of cluster of differentiation 163 (CD163) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of cluster of differentiation 206 (CD206) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of adhesion G-protein coupled receptor E (ADGRE) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of inducible nitric oxide synthase (INOS) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of monocyte chemoattractant protein-1 (MCP1) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of tumor necrosis factor alpha (TNFa) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of leptin (LEPD) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of adiponectin (ADIPOQ) measured by PCR.
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Inflammatory proteins found in adipose tissue measured using the Olink Target Inflammation Panel (includes 96 inflammation-associated proteins)
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Protein cargo of adipose extracellular vesicles measured using mass spectrometry
Timeframe: Pre-exercise, immediately post-exercise, and 3 hours after exercise