A Study of JNJ-77242113 in Participants With Moderately to Severely Active Ulcerative Colitis

Inclusion Criteria: * Signed informed consent form 18 years of age or older * Documented diagnosis of ulcerative colitis (UC) of at least 12 weeks prior to screening * Moderately to severely active UC as per the modified Mayo score * Demonstrated inadequate response to or intolerance of conventional therapy and/or advanced therapy as defined in the protocol Exclusion Criteria: * Participants with current or prior diagnosis of fulminant colitis and/or toxic megacolon * UC limited to rectum only or to less than (\<) 15 centimeters (cm) of colon * Presence of a stoma * Presence or history of fistula * History of extensive colonic resection (example, \<30 cm of colon remaining) * Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, Crohn's colitis or clinical findings suggestive of Crohn's disease