SeQuent ® Please CIS for the Treatment of INtracranial Atherosclerotic Stenosis

Inclusion criteria

• . Aged 18 to 80 years old (including boundary value), gender is not limited;
• . The target lesion of the patient is a symptomatic intracranial atherosclerotic stenosis lesion (applicable to Sub-study A only) or restenosis lesions after interventional therapy (applicable only to Sub-study B);
• . Symptomatic intracranial arterial stenosis (intracranial segment of internal carotid artery (Petrous segment and above), middle cerebral artery, intracranial segment of vertebral artery, basilar artery, etc.) within 6 months, the degree of stenosis of the diseased artery is between 70% and 99% (WASID method);
• . Patients with symptoms occurring more than once (symptoms refer to stroke or transient ischemic attacks) after intensive drug therapy of internal medicine (including antiplatelet therapy, antihypertensive therapy, hypoglycemic therapy and lipid-lowering therapy);
• . The intracranial arterial stenosis lesion to be treated is a single lesion;
• . Patients with at least 1 risk factor for intracranial atherosclerotic plaque, including previous or existing hypertension, hyperlipidemia, diabetes, smoking;
• . Preoperative mRS ≤ 2, and NIHSS≤8;
• . Patients whose life expectancy is greater than 12 months as assessed by the investigator.

Exclusion criteria