First Clinical Evaluation of Heart Transplantation With Grafts Preserved Using an Ex-vivo Extended Perfusion System

Inclusion Criteria: * Patients over 18 years of age * Patients suffering from irreversible terminal heart failure with a medical indication for heart transplantation but who cannot be transplanted (per the graft allocation policy in France) or assisted (technical impossibility, contraindication, patient's refusal) and for whom a favourable and motivated opinion from the Multidisciplinary Consultation Meeting (RCP) of the cardiac surgery department of the Hospital Pitié-Salpêtrière has been made * Having given their informed consent in writing Exclusion Criteria: * Technical obstacles which would generate an excessive surgical risk for the patient according to the medical opinion such as comorbidities or associated pathology not compatible with a transplant * Known ongoing sepsis, defined as positive blood culture immediately prior to transplant (including with ventricular assist device) * Candidate patient for Combined Organ Transplantation * Patient protected by law (guardianship, curatorship, deprived of liberty) * No affiliated with or entitled to a French social security scheme (AME included) * Pregnant or breast-feeding female * Current participation in another interventional study (category 1 of French Jardé law) or being in the exclusion period at the end of a previous study * Patient unable to understand the information provided during the informed consent procedure