The Effect of the Egg Shell Nanoparticles Combined With Titanium Dioxide Nanoparticles (NCT06025084) | Clinical Trial Compass
CompletedPhase 1
The Effect of the Egg Shell Nanoparticles Combined With Titanium Dioxide Nanoparticles
Egypt24 participantsStarted 2022-12-01
Plain-language summary
Dentin hypersensitivity is one of the most commonly occurring clinical dental conditions which is characterized by short and sharp pain which arises from exposed dentin in response to external stimuli, which typically are thermal, evaporative, tactile, osmotic or chemical.
Hypersensitive dentin is mostly found in buccal tooth areas, in which enamel is missing because of abrasion, attrition, or erosion. The most generally accepted theory regarding the mechanism of dentin hypersensitivity is the hydrodynamic theory. It proposes that a pain-provoking stimulus increases the flow of the dentinal tubular fluid and consequently, stimulates the nerves around the odontoblasts, leading to dentin hypersensitivity.
Who can participate
Age range
20 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
1- For patients;
* Age between 20 and 55 years
* Patients in good systemic health with clinically elicitable dentin hypersensitivity
* Absence of contraindications to the proposed therapies as allergy. 2 - For teeth;
* Absence of local pathologies (e.g., caries and fractures)
* Visual analog scale (VAS) score ≥3
Exclusion Criteria:
* \-- For patients;
* Use of any desensitizing toothpaste for previous 3 or 4 months.
* Taking analgesics/anti-inflammatory drugs at the time of the study, pregnancy, and smoking.
2 -For teeth ;
* Teeth with abrasion and attrition.
* Carious lesions on the selected or neighboring teeth, defective restorations
* Any professional desensitizing therapy on the selected teeth during the last 6 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Assessment of dentin hypersensitivity
Timeframe: from baseline to 2 months after the treatment day.