Stopped: Business objectives have changed
The purpose of this study is to find a safe, tolerable, and efficacious dose of BMS-986466 when given orally, in combination with adagrasib with or without cetuximab in participants with advanced KRAS G12C-mutant non-small cell lung cancer (NSCLC), pancreatic duct adenocarcinoma (PDAC), biliary tract cancer (BTC), or colorectal cancer (CRC).
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Part 1: Number of Participants With Dose Limiting Toxicity (DLTs)
Timeframe: Cycle 1 (Each cycle consist of 28 days)
Part 1: Number of Participants With Adverse Events (AEs)
Timeframe: From first dose until 100 days after last dose (Up to approximately 5 months)
Part 1: Number of Participants With Serious Adverse Events (SAEs)
Timeframe: From first dose until 30 days after last dose (Up to approximately 3 months)
Part 1: Number of Participants With AEs Leading to Discontinuation
Timeframe: From first dose until 30 days after last dose (Up to approximately 3 months)
Part 1: Number of Participants Who Died
Timeframe: From first dose until 100 days after last dose (Up to approximately 5 months)
Part 2 Objective Response Rate (ORR) Assessed by Blinded Independent Central Review (BICR) as Per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
Timeframe: From randomization untill disease progression or death, whichever occurs first (up to approximately 5 months)