This exploratory trial investigates the effect of a chicken extract supplement on mental energy and its potential underlying mechanisms of action among healthy adults using a randomized, double-blind, placebo-controlled clinical trial design. Mental energy is a multi-dimensional construct comprising transient feelings about fatigue, vigor and motivation and cognitive performance in terms of sustained attention and reaction time. A sub-study investigates the immediate biochemical changes after taking chicken extract.
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Reaction time and sustained attention (composite) assessed by Cogstate Brief Battery (CBB)
Timeframe: At baseline and on Day 14
Reaction time assessed by Deary-Liewald reaction time task
Timeframe: At baseline and on Day 14
Sustained attention assessed by psychomotor vigilance test
Timeframe: At baseline and on Day 14
Sustained attention assessed by trail making test
Timeframe: At baseline and on Day 14
Fatigue assessed by Profile of Mood States (POMS)
Timeframe: Daily from baseline to Day 14
Fatigue assessed by visual analogue scale (VAS)
Timeframe: Daily from baseline to Day 14
Vigor assessed by Profile of Mood States (POMS)
Timeframe: Daily from baseline to Day 14
Vigor assessed by visual analogue scale (VAS)
Timeframe: Daily from baseline to Day 14
Motivation assessed by visual analogue scale (VAS)
Timeframe: Daily from baseline to Day 14
Cerebral blood flow using arterial spin labelling magnetic resonance imaging (MRI)
Timeframe: At baseline and on Day 14
Cerebral oxygenation using functional MRI blood oxygenation level dependent (BOLD) imaging
Timeframe: At baseline and on Day 14
Whole body metabolic rate using indirect calorimetry
Timeframe: At baseline and on Day 14
Plasma global metabolome (metabolic profile) using liquid chromatography mass spectrometry (LCMS)
Timeframe: At baseline and on Day 14
Salivary cortisol level
Timeframe: At baseline and on Day 14
Plasma carnosine
Timeframe: At baseline and on Day 14
Plasma anserine
Timeframe: At baseline and on Day 14
Plasma L-histidine
Timeframe: At baseline and on Day 14
Plasma methylhistidine
Timeframe: At baseline and on Day 14
Plasma beta-alanine
Timeframe: At baseline and on Day 14