The Impact of the Physiological Response to Sugar on Brain Activity and Behavior (NCT06015490) | Clinical Trial Compass
CompletedNot Applicable
The Impact of the Physiological Response to Sugar on Brain Activity and Behavior
United States7 participantsStarted 2023-09-01
Plain-language summary
The goal of this pilot study is to test the feasibility of assessing how biological factors and chemical properties of sugars may influence metabolism and food reward in humans. The main questions it aims to answer are:
ā¢ Can differences in appetitive responses and neural activations to sucrose (table sugar) and its chemical components (glucose and fructose) be measured and quantified?
This study is a crossover design, meaning every participant will complete every condition. Participants will consume beverages containing sucrose, glucose, or fructose, which are each novelly flavored, 6 times within a week. During one of the consumption times, energy expenditure, carbohydrate oxidation, and blood glucose will be measured in the lab before and for 2 hours after consumption. After participants have consumed each condition, they will undergo a tasting task in the MRI scanner, neural responses to receipt of the beverages are measured.
Who can participate
Age range18 Years ā 45 Years
SexALL
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Inclusion criteria
ā. BMI between 18.5-25 kg/m2
ā. Not pregnant or planning to become pregnant during study participation
ā. Residing in the Roanoke area and/or willing/able to attend sessions at the Fralin Biomedical Research Institute (FBRI) at Virginia Tech Carilion
ā. Weigh at least 110 lbs
Exclusion criteria
ā. Current inhaled nicotine use
ā. History of alcohol dependence.
ā. Current or past diagnosis of cardiometabolic disease or problems, including diabetes, endocrine, heart, or thyroid problems, that may influence study outcomes
ā. Hemoglobin A1C \>5.7%
ā. Taking medications known to influence study measures (including attention-deficit/hyperactivity disorder (ADHD), allergy, antidepressant, antipsychotic, anxiolytic, birth control, blood pressure, blood glucose, cholesterol, thyroid, sleep, or weight loss medications)
What they're measuring
1
Change in Preference- Subjective Liking Ratings for Each Beverage on a Scale
Timeframe: Immediately after informed consent and in the post-test session approximately 5 weeks later
Trial details
NCT IDNCT06015490
SponsorVirginia Polytechnic Institute and State University