Standard Therapy and TIPS for Moderate to High-risk Esophageal and Gastric Variceal Bleeding

Inclusion Criteria: * Confirmed as liver cirrhosis (based on clinical, laboratory examination, imaging, or liver biopsy), and the disease is caused by viral hepatitis cirrhosis or alcoholic cirrhosis. * 16mmHg ≤ HVPG ≤ 20mmHg * Gastroscopy confirms moderate to severe esophageal and gastric varices (EV and GOV1 types) with at least one history of EGVB * Age 18-80 years old and liver function CTP grading B or C\<14 points * Sign the informed consent form; * Expected survival time greater than 1 year Exclusion Criteria: * Patients with cirrhosis associated with non viral hepatitis or Alcoholic hepatitis Taking NSBBs or other medications to treat portal hypertension within the past 6 weeks * Contraindication for the use of NSBBs, such as bronchial asthma, Cardiogenic shock, heart block (Ⅱ - Ⅲ degree atrioventricular block), severe or acute heart failure and sinus bradycardia * Simultaneously taking drugs that affect the metabolism and absorption of NSBBs in the body * TIPS recanalization treatment due to shunt failure * Serum total bilirubin\>85.5 µ mol/L * Preoperative evaluation reveals the presence of liver cancer or extrahepatic tumors, severe organ dysfunction, and other factors that affect expected survival disease * Intractable ascites or hepatorenal syndrome * Concomitant portal vein cavernous degeneration or severe portal vein system thrombosis * Women who plan to become pregnant or are already pregnant or breastfeeding