Contribution of Nasal High Flow in Pneumology Assessed in Acid-Free Hypercapnic Acute Respiratory… (NCT06008587) | Clinical Trial Compass
TerminatedNot Applicable
Contribution of Nasal High Flow in Pneumology Assessed in Acid-Free Hypercapnic Acute Respiratory Failure
Stopped: Impossible to achieve inclusion goals, fewer patients in reality than expected
France, Monaco16 participantsStarted 2024-02-27
Plain-language summary
The hypothesis is that Nasal High Flow therapy for patients with Hypercapnic Acute Respiratory Failure without acidosis, in addition to standard treatment would improve the care.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Major patient ≥ 18 years old
* Medical diagnosis of Acute Respiratory Failure less than 48 hours
* With partial pressure of carbon dioxide (PaCO2) \> 45 and pH \> 7.35 for less than 48 hours, with no indication of Non-Invasive Ventilation (NIV) placement
* Underlying terrain of known or unknown chronic respiratory pathology (may be unknown at time of diagnosis) Examples : COPD, Bronchiectasis, Pulmonary fibrosis, asthma, sequelae pathologies …
* All etiologies (infectious, cardiac decompensation, trauma, etc.)
* Having given informed consent
* Patient under a social security scheme
* Possibility to include a patient having already been included in the study but suffering from a new episode of hypercapnic non acidic Acute Respiratory Failure with a free interval of 3 months
Exclusion Criteria:
* Restrictive chronic neuromuscular or kyphoscoliotic respiratory insufficiencies
* Drug-induced Acute respiratory failure
* Pneumothorax (X-ray pulmonary detachment)
* Oxygen poisoning. In this case, PaCO2 will be asset again later with the purpose to include after oxygenotherapy decrease for a target SpO2 of 92% maximum
* Severe Acute Respiratory Syndrome (SARS) Coronavirus 2 (COVII) Pneumonia
* Tracheostomy
* Prior treatment with chronic or initiated NIV just prior to treatment (e.g. Intensive Care Unit)
* Respiratory Severity Criteria for Resuscitation Management
* Agitation or non-cooperation
* Pregnancy or breastfeeding
* Person participating in other biome…
What they're measuring
1
Failure of the Nasal High Flow
Timeframe: Up to 2 weeks
Trial details
NCT IDNCT06008587
SponsorCentre Hospitalier Intercommunal de Toulon La Seyne sur Mer