A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee

Inclusion Criteria: * Males or females 18 years of age or older * Diagnosis of OA of the index knee by a combination of clinical and radiographic findings. * OA of the index knee with Kellgren and Lawrence radiographic classification (Grades 2-4 inclusive), * Patients who have failed to adequately respond for at least 6 months to at least two osteoarthritis therapies within the last 12 months * Overall index knee pain score above minimum required WOMAC Pain scale. * Body mass index \< 40 kg/m2 * Using birth control, sterile or post-menopausal. * Able to understand and provide written informed consent Exclusion Criteria: * Kellgren and Lawrence radiographic grade 1 OA of the knee * Use of pain medication less than 5 days before the baseline visit * Regular use of anticoagulants * Symptoms that could indicate meniscal displacement or an IA loose body. * Corticosteroid injection into the index knee within 3 months prior to screening. * Viscosupplement or any other autologous or allogeneic product into the index knee within 6 months prior to screening. * Patients with known hypersensitivity reactions to ASA or any of its constituents. * Knee surgery on the index knee within 12 months prior to screening and/or planned knee surgery during the study * Knee surgery on the contralateral knee within 6 months prior to screening and/or planned knee surgery during the study * Acute index knee trauma within 3 months prior to screening * Knee effusion requiring aspiration of the index or…