Effects of MetAP2 Inhibition on Bioenergetics and Aging-associated Characteristics in Adipose Tis… (NCT05989035) | Clinical Trial Compass
CompletedNot Applicable
Effects of MetAP2 Inhibition on Bioenergetics and Aging-associated Characteristics in Adipose Tissue in Healthy Participants
United States31 participantsStarted 2020-08-31
Plain-language summary
This study is being done to collect Adipose tissue from young and older individuals and gather data on the effect of methionine aminopeptidase protein (MetAP2) inhibition on that Adipose tissue in the laboratory.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Group 1 cohort are male or female participants between 18 and 30 years old
. Group 2 cohort are male or female participants ≥ 65 years old
. Body mass index (BMI) ≤ 40 kg/m2
. Weight stable (±5 kg) for the last 3 months prior to the Screening visit
. Sedentary (\<20 min of activity, 3x/week).
. Able to speak and understand written and spoken English
. Willing and able to comply with scheduled visits, laboratory tests, and other study procedures
. Participant has voluntarily signed and dated an informed consent form, approved by an Institutional Review Board/Independent Ethics Committee, and provided Health Insurance Portability and Accountability Act authorization (HIPAA) or other privacy authorization prior to any participation in study
Exclusion criteria
. Diagnosis of type 1 diabetes mellitus
. Diagnosis of type 2 diabetes mellitus (HbA1C ≥ 6.5)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The effect of MetAP2 inhibition on senescence markers in adipose tissue explants
Timeframe: 4 weeks
2
The effect of MetAP2 inhibition on adipose tissue quality in adipose tissue explants
Timeframe: 4 weeks
3
The effect of MetAP2 inhibition on adipose tissue quality in adipose tissue explants
Timeframe: 4 weeks
Trial details
NCT IDNCT05989035
SponsorAdventHealth Translational Research Institute