Efficacy Study II on Remote Ischemic Conditioning for the Prevention of Stroke-Associated Pneumonia

Inclusion Criteria: * Age≥18 years old; * Diagnosis of acute ischemic stroke; * Remote ischemic conditioning or sham-remote ischemic conditioning can be treated within 24 hours after stroke onset * NIHSS score≥4; * Subject or his or her legally authorized representative was able to provide informed consent. Exclusion Criteria: * During the screening period, body temperature ≥ 38 ℃; * Evidence of lung infection, urinary tract infection or other infectious diseases during the screening period * Expected lifespan less than 7 days * Mechanical ventilation is expected to be required within 7 days; * Anti-infective drug were used within 7 days prior to stroke; * Uncontrolled hypertension with medication (defined as systolic blood pressure ≥200 mmHg and/or diastolic blood pressure ≥110 mmHg); * There are contraindications for remote ischemic conditioning (such as skin and soft tissue injury, fractures, peripheral arterial disease, etc. in the upper limbs); * History of autoimmune disease or malignancies; * Use of immunosuppressive drug within the preceding 3 months; * Pregnant or lactating, or pregnancy test positive; * Current participation in another investigational trial; * Other conditions are not suitable for this trial as evaluated by researchers.