Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication adherence monitor and would allow for the physician, counselor, patient, or family member to remotely verify that a physician-prescribed dose has been taken.
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
LC-MS based Proteome analysis of dermal interstitial fluid in non opioid use disordered patients
Timeframe: 1 day
Methadone Concentration in ISF before and after a dose
Timeframe: 1 day
Methadone Concentration in blood before and after a dose
Timeframe: 1 day
Concentration of Methadone in ISF with LC-MS versus Electrochemical Assay
Timeframe: 2 days
Concentration of Methadone in blood with LC-MS versus Electrochemical Assay
Timeframe: 2 days
Pearson Correlation of Methadone between ISF and Blood
Timeframe: 2 days
Pearson Correlation between DPV and LC-MS ISF Methadone
Timeframe: 2 days
Pearson Correlation between DPV and LC-MS ISF EDDP
Timeframe: 2 days
Pearson Correlation between DPV and LC-MS blood EDDP
Timeframe: 2 days
EDDP concentration in ISF before and after daily dose of methadone
Timeframe: 1 day
EDDP concentration in blood before and after daily dose of methadone
Timeframe: 1 day
EMDP concentration in ISF before and after daily dose of methadone
Timeframe: 1 day
EMDP concentration in blood before and after daily dose of methadone
Timeframe: 1 day
Pearson Correlation of Methadone to Metabolite Ratio ( MMR ) between ISF and Blood using LC-MS
Timeframe: 2 days
Pearson Correlation of Methadone to Metabolite Ratio ( MMR ) between ISF and Blood using DPV
Timeframe: 2 days