The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease. MSC cultured are loaded on a collagen scaffold, included into autologous platelet rich plasma clot and implanted in the bone defect.
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Change in clinical attachment level (CAL)
Timeframe: Follow-up includes evaluation at 3, 6, 9 and 12 months post-transplantation
Change in probing pocket depth (PPD)
Timeframe: Follow-up includes evaluation at 3, 6, 9 and 12 months post-transplantation
Gingival recession (GR)
Timeframe: Follow-up includes evaluation at 3, 6, 9 and 12 months post-transplantation
Change in bone density
Timeframe: Follow-up includes evaluation at 3, 6, 9 and 12 months post-transplantation
Change in Tooth Mobility (TM)
Timeframe: Follow-up includes evaluation at 3, 6, 9 and 12 months post-transplantation
Change in bone depth
Timeframe: Follow-up includes evaluation at 3, 6, 9 and 12 months post-transplantation