The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.

Inclusion Criteria: * Presence of carotid stenosis on either ultrasound or CT scan. * Planned to undergo carotid endarterectomy. Exclusion Criteria: * Autoimmune disease * Any regular immunosuppressive treatment \[Inhaled or topical steroids are permissible\] * Modified Rankin Scale score of ≥4 at screening * Known active hepatic disease or alanine aminotransferase (ALT) \> 2xULN * Severe chronic kidney disease (defined as eGFR \< 30 ml/min/1.73m2) * Allergy or intolerance to aldesleukin * Signs or symptoms of active infection * History of human immunodeficiency virus (HIV), hepatitis B or C * Current malignancy requiring active treatment * Vaccine within 4 weeks prior to screening or plans for vaccination during study period * Women of child-bearing potential and pregnancy * Women who are breast-feeding * Clinically relevant medical or surgical conditions that, in the opinion of the