Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Pa… (NCT05970861) | Clinical Trial Compass
CompletedNot Applicable
Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients
Kazakhstan75 participantsStarted 2023-09-01
Plain-language summary
The efficacy of natural foods such as freeze-dried mare's milk (Saumal) in post-COVID syndrome therapy has not been studied. The literature review has shown that researchers have focused more on evidence-based medications and less on natural products. Some raw foods, such as freeze-dried mare's milk, contribute to forming complete immune complexes and have antioxidant, membrane stabilizing, and antiviral effects.
The use of Saumal proved its effectiveness in patients suffering from chronic hepatitis C. After 4 weeks of using freeze-dried mare's milk, the biodiversity of the intestinal microbiome was increased. The content of bacteria secreting short-chain fatty acids also increased.
The study aims to confirm these effects at the gene level in patients who underwent COVID-19. This study will allow us to develop a highly evidence-based component of rehabilitation therapy in patients after COVID-19.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Age 18 years and older;
✓. Patients in rehabilitation after COVID-19;
✓. Signed informed consent;
✓. Presence of patient's history of COVID-19, reliably established by PCR+ /presence of IgG/ diagnosis of coronavirus pneumonia on Computer Tomography based on discharge from hospital or outpatient records.
Exclusion criteria
✕. Chronic inflammatory bowel disease;
✕. Gut microbiota transplantation;
✕. Chronic pancreatic disease, period of exacerbation;
✕. Liver cirrhosis, Metavir stage 3-4;
✕. Any disease in the decompensation stage;
✕. Neuralgic and psychological disorders that interfere with the study;
✕
What they're measuring
1
Gut Microbiome
Timeframe: 4 weeks
2
Antiphospholipid Antibodies
Timeframe: 4 weeks
3
Biochemical Blood Analysis (Uric Acid)
Timeframe: 4 weeks
4
Quality of Life Changes
Timeframe: 4 weeks
Trial details
NCT IDNCT05970861
SponsorAsfendiyarov Kazakh National Medical University