Acromegaly is a rare chronic disease due to excessive secretion of growth hormone (GH) and insulin-like growth factor-I (IGF-I), caused in over 98% of cases by GH-secreting pituitary adenoma. Prolonged exposure to GH/IGF-I excess is the cause of increased mortality and morbidity in these patients. Arthropathy occurs in about 75% of acromegalic patients. Any joint may be affected, with the development of osteoarthritis, arthralgia, and an increase in fracture risk. The aims of the present project are to evaluate the dimensions of hands and feet with the 3D scanner method and to perform a quantitative analysis of movement through Gait Analysis technique in de novo patients with acromegaly (group # 1) and in patients with different disease status (group #2).
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Change in serum concentration of GH and IGF1
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1
Change in postural
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1
Gait analysis
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1
Change in function of the foot - angle ankle joint
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1
Change in function of the foot - angle subtalar joint
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1
Change in function of the foot - angle metatarsophalangeal joint of the big toe
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1
Change in Function of the hand - Dreiser functional index
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1
Change in Function of the hand - Duruöz hand index
Timeframe: At baseline in population #1 and # 2 and at 3, 6, 12 months after intervention in population #1