Individuals with Fragile X Syndrome show differences in how they understand and learn language from infancy. They frequently have lifelong delays in speech and language as well. In addition, they experience other auditory symptoms, including being very sensitive to certain sounds as well as being more sensitive than others to loud sounds. The underlying brain activity for sound perception and speech learning in Fragile X is not well understood, especially in the infant, toddler, and preschool years. This study uses behavioral assessment of speech and language abilities, neuroimaging, and hearing tests to understand how speech and hearing are different in children with Fragile X Syndrome.
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Change in Mullen Scales of Early Learning
Timeframe: at single study visit between ages of 2-4 years inclusive
Changes in oxygenated and deoxygenated hemoglobin concentration in response to sounds in language regions of the brain
Timeframe: at single study visit between ages of 2-4 years inclusive
Changes in amplitude of mismatch negativity response during sound discrimination
Timeframe: at single study visit between ages of 2-4 years inclusive
Changes in hearing thresholds
Timeframe: at single study visit between ages of 2-4 years inclusive
Otoacoustic Emissions (OAEs)
Timeframe: at single study visit between ages of 2-4 years inclusive
Changes in tympanometric pressure profile in the inner ear
Timeframe: at single study visit between ages of 2-4 years inclusive