WithdrawnNot Applicable

Anesthesia, TIVA, Balanced Anesthesia, NK Cell

Stopped: participants are no longer being examined or receiving intervention

0Started 2018-04-16

Plain-language summary

Anesthetic method was reported to have an impact on postoperative long-term outcome in cancer patients. In this study, we will investigate the effect of different anesthetic methods on NK cell activity, cytokine response and postoperative outcome in colorectal cancer patients undergoing CRS and HIPEC. We will compare propofol-based total intravenous anesthesia (TIVA) with balanced anesthesia to determine the effect of propofol, inhalation agent, and opioid on tumor genesis, recurrence, NK cell activity, cytokine response, and postoperative outcome.

Who can participate

Age range20 Years – 70 Years

SexALL

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Inclusion criteria

✓. Colorectal cancer patients undergoing elective cytoreductive surgery and HIPEC (20-70 yrs old)
✓. American Society of Anesthesiologists physical status I, II, III

Exclusion criteria

✕. Patients under 20 years old.
✕. Patients with long-term steroid therapy or immunosuppressive therapy.
✕. Patients with long-term NSAIDs therapy.
✕. Patients who cannot communicate with other person or with cognitive disorder.
✕. Patients who cannot read the consent form.

What they're measuring

Postoperative immune function (NK cell count)

Timeframe: Postoperative day 1

Trial details

NCT IDNCT05951842

SponsorGangnam Severance Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-02-28

View on ClinicalTrials.gov More Colorectal Cancer trials